Synthesis and Anxiolytic Activity of 2-(Substituted)- 5-[(N-Benzotriazolomethyl)-1,3, 4-Thiadiazolyl]-4- Thiazolidinone: (DDIPIJ) - Lupine Publishers

Synthesis and Anxiolytic Activity of 2-(Substituted)- 5-[(N-Benzotriazolomethyl)-1,3, 4-Thiadiazolyl]-4- Thiazolidinone by V. K. Singh, Peeyush Bharadwaj and Poonam Rishishwar in Drug Designing & Intellectual Properties International Journal (DDIPIJ) in Lupine Publishers 

1,2,3- Benzotriazole (BTA) is a heterocyclic compound with three nitrogen atoms. It is a polar and colourless compound which can be used for its great versatility. The enormous investigations on derivatives of benzotriazole reveal wide applicability of this molecule for tagging and delivering huge number of heterocyclic nuclei. In the present work synthesis of several derivatives of 2-(substituted)-5-[(n-benzotriazolomethyl)-1,3,4-thiadiazolyl]-4-thiazolidinone has been synthesized and are evaluated for their anxiolytic activity. The antianxiety activities of the synthesized derivatives were evaluated using EPM test and Bright and dark box test experimental models of anxiety. All results were expressed as mean± standard error mean (SEM) and analysed by one-way ANOVA. Post-hoc comparisons were performed by applying Dunnefs test. P <0.05 was considered statistically significant.

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