Camphor Sulfonic Acid Catalyzed Facile and Atom Economical Access to Highly Substituted Piperidines via One Pot Multi Component Reactions: (AOICS) -Lupine Publishers

Camphor Sulfonic Acid Catalyzed Facile and Atom Economical Access to Highly Substituted Piperidines via One Pot Multi Component Reactions by Murlidhar Shingare in Archive of organic and inorganic chemical sciences(AOICS) in Lupine Publishers

A simple and efficient protocol has been developed for the synthesis of highly substituted Piperidines derivatives. This strategy demonstrated five component reactions of two equivalents of aldehydes, two equivalents of anilines and (3-keto esters in ethanol using 10 mol% of camphor sulfonic acid at reflux. The significant features of the present protocol include excellent yield, shorter reaction time, and easy work up procedure, broad substrate scope, high atom economy and formation of C-C and C-N bond in a single step operation.

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