Showing posts with label Open access ophthalmology journals. Show all posts
Showing posts with label Open access ophthalmology journals. Show all posts

Monday, 3 October 2022

Lupine Publishers| Visual Impairment and its Rehabilitation: A Review

 Lupine Publishers| Journal of Ophthalmology



Abstract

Visual impairment (VI) is a condition of reduced visual performance that cannot be remedied by refractive correction (spectacles or contact lenses), surgery or medical methods. Visual Impairment is a broader term that encompasses both Low vision and Blindness. The prevalence of visual impairment is estimated to be around 2.2 billion in the world as per World Health Organization (WHO). Causes of Visual Impairment differs significantly in different regions. Saying that, still cataract and refractive errors are main causes of visual impairment globally. Owing to its negative impact on the individual’s dailies, professional life, productive time, confidence, and self-respect, VI needs to be addressed timely and appropriately. Visual impairments do have profound consequences for the individual, however effective rehabilitation services can restore independence and therefore ameliorate these consequences and restore the individual’s quality of life.

Keywords: Visual Impairment; Blindness; low Vision; Rehabilitation; Optical Devices; Non-Optical Devices

Introduction

Impairment of any kind (sensorial or motor) is a bane for any human being. With visual impairment being one of the leading causes of sensorial impairment, it is necessary to acknowledge its prevalence, causes and methods to avoid them, if possible. Also, at the same time, it is important to understand that the term “visual impairment”, “blindness” and “Low vision” are not synonymous; rather visual impairment includes low vision as well as blindness. Simply, Visual impairment (VI) is a condition of reduced visual performance that cannot be remedied by refractive correction (spectacles or contact lenses), surgery or medical methods [1]. Various definitions of visual impairment have been given by various concerned authorities. International Statistical Classification of Diseases and Related Health Problems (ICD) defines visual impairment categories primarily on the basis of recommendations made by a World Health Organization (WHO) Study Group in 1972 [2] and defines as:

• low vision is defined as visual acuity of less than 6/18, but equal to or better than 3/60, or a corresponding visual field loss to less than 20 degrees in the better eye with best possible correction
• blindness is defined as visual acuity of less than 3/60, or a corresponding visual field loss to less than 10 degrees in the better eye with best possible correction.

Since, the ICD definition of visual impairment is based on best corrected visual acuity (BCVA), which exclude uncorrected refractive error as a cause of visual impairment, leading to substantial underestimation of the total visual impairment burden by about 38%, Lalit Dandona [3] and colleagues debated a revision in these definitions and defined:

a person with low vision as one who has impairment of visual functioning even after treatment and/or refractive correction, and has a visual acuity of less than 6/18 to light perception, or a visual field of less than 10° from the point of fixation, but who uses, or is potentially able to use, vision for the planning and/or execution of a task [4].
• blindness is defined as visual acuity of less than 6/60, equivalent to central visual field of 20° [5,6].
• A guideline has been instated to define “Legal Blindness” by Social Security Act to help people receive government assistance, such as Social Security disability benefits. Legal Blindness is defined as:

Remaining vision in the better eye after best correction is 20/200 (6/60) or less OR contraction of the peripheral visual fields in the better eye (A) to 10 degrees or less from the point of fixation; or (B) so the widest diameter subtends an angle no greater than 20 degrees [7].
Some other definitions and types of blindness adopted by different countries and institutions are:

Avoidable Blindness

It is the blindness that could be either treated or prevented by known, cost effective means. It can either be preventable or curable. It includes:

• Cataract
• Glaucoma
• Diabetic retinopathy
• Corneal infections
• Ocular trauma
• Refractive error

Curable Blindness

It is the stage of blindness where the damage is reversible by prompt management. E.g.: Cataract

Preventable Blindness

It is the type of blindness in which the loss of vision that could have been completely prevented by effective preventive and prophylactic measures
Example: Xerophthalmia

Manifest Blindness

It restricts the accomplishment of tasks for daily living leading to impairment in mobility.
Vision less than 1/60 to just perception of light in the better eye with best correction is considered as manifest blindness

Absolute Blindness

It restricts the ability of even perceiving the light. E.g.: Optic atrophy.

Economic Blindness

It is the level of blindness that prevents an individual from earning his wages. Vision less than 6/60 to 3/60 in the better eye with best correction is considered as economic blindness

Social Blindness

It hampers an individual from socially interacting with the family and peer groups in a satisfactory manner. Vision less than 3/60 to 1/60 in the better eye with best correction is considered as social blindness.

Classification:

The classification of visual impairment varies worldwide [8]. Since ICD is considered the standard worldwide classification therefore, the ICD definitions of visual impairment are used most often for worldwide estimates of visual impairment. The ICD-11 classification of visual impairment (which specifies all levels of vision loss, for each eye, and is used for coding a visual impairment as the diagnosis) is listed in the table below [2] (Table 1):

Table 1:

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In the above table, it should be noted that in the revision of the ICD-10 categories of visual impairment proposed in 2003 by a WHO consultation on the development of standards for characterization of vision loss, low vision is replaced by two categories: moderate visual impairment (presenting visual acuity less than 6/18 but equal to or better than 6/60) and severe visual impairment (presenting visual acuity less than 6/60 but equal to or better than 3/60) [9]. Also, the previous classifications of visual impairment considered visual acuity as the only determining factor for categorizing visual impairment; loss of function due to hemianopia, loss of contrast sensitivity, photophobia, visual distortion, diplopia, or visual perceptual difficulties were not considered. These factors have been addressed on ICD-10 and ICD-11. Vision impairment results as an involvement of more than one factor which may include visual acuity, visual field, and contrast sensitivity. Therefore, these are the most clinically useful quantifiers of visual impairment [8].

Prevalence and Incidence:

According to World Health Organization, globally, at least 2.2 billion people have a vision impairment or blindness, of whom at least 1 billion have a vision impairment that could have been prevented or has yet to be addressed [10], among whom 1 billion people includes those with moderate or severe distance vision impairment or blindness [10] However, with the introduction of the global initiative to eliminate avoidable blindness (vision 2020: the right to sight), many agree that the initiative is in the right direction to reduce the prevalence of avoidable blindness [11]. Estimates of the number of visually impaired persons vary, depending upon the criteria used [12]. In 2002, it was estimated that with bestcorrected vision there were 161 million individuals with VI globally [13]. However, when the prevalence of uncorrected refractive error was included, this value increased substantially to 314 million individuals with VI [14]. This implies that an additional 153 million individuals were visually impaired from uncorrected refractive error alone [14]. This statistics stress upon the underestimation of total visually impaired population if uncorrected refractive error is to be looked. Thus, the importance of correction and management of refractive error is significantly high for the management of visual impairment [15].
An interesting fact is that, the majority of the visually impaired population are among the elderly and shows female preponderance. The incidence of visual impairment increases with age; more than two-thirds of persons with low vision are over the age of 65 [16] The global prevalence of blindness is greater in women than in men [17], especially among high-income regions which may be attributed to longer life expectancies and lack of access to health care services especially in rural areas [18]. Visual impairment secondary to uncorrected refractive error starts at a younger age than cataract [19], therefore childhood blindness must not be undermined. Vision impairment, particularly among children interferes with most life experiences [20]. World Health Organization (WHO) estimates the number of blind children in the world to be approximately 1.4 million, out of which three quarter resides within developing and underdeveloped countries like Nepal.20 According to mid-term review of Nepal Blindness Survey 2010, an estimated 1,013,041 children less than 16 years of age (prevalence among under 16 age group assumed to be 10% based on different studies varying from 3 to 20%); 1,164,053 persons between 16-35 years of age have uncorrected refractive error for distance (estimated prevalence 15%) [21].

Causes and Risk Factors:

Not only the ocular morbidities, but also the systemic health conditions including trauma can pre-dispose a person to ocular abnormalities, rendering them visually impaired. The causes of visual impairment are numerous, including not only congenital and acquired ocular conditions, but systemic diseases with ocular complications and neurological insult and trauma. The major causes of visual impairment in vary widely from region to region, being largely determined by socioeconomic development, and the availability of primary health care and eye care services20 The Vision 2020- Right to Sight has identified five priorities for elimination of preventable blindness and they are: Cataract, Trachoma, Onchocerciasis, Childhood blindness and Refractive errors and low vision services. However, the causes of visual impairment are largely determined by the economy of the country. Refractive error is one of the most common causes of visual impairment around the world and the second leading cause of treatable blindness19 which remain as a common cause in both developed and developing countries. Globally, the leading causes of blindness and moderate and severe VI include uncorrected refractive error, cataract, and macular degeneration [22]. The major causes of blindness in developed and developing countries are shown in the table below (Table 2):

Table 2:

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The incidence of these conditions increases with age. So, increasing age is the single- most risk factor for visual impairment. However, the causes of visual impairment among children are different from those of adults. Among children, the causes of vision impairment vary considerably across countries; for example, in developing countries congenital cataract is a leading cause, whereas in developed it is more likely to be retinopathy of prematurity, uncorrected refractive errors remain a common cause [20]. Though the global burden of childhood blindness is insignificant in comparison to that of adult, children have life time of blindness ahead. So, the proper cause and management should be instituted more readily among pediatric age groups. According to Nepal Blindness Survey (NBS), 1981 and Mid-term Review of NBS, 2010, the major causes of childhood blindness and the main avoidable causes in Nepal are:

• Cataract
• Glaucoma
• Retinopathy of prematurity is emerging in major cities
• Refractive errors
• Low vision, which encompasses visual impairment and blindness from untreatable causes

Impact:

Visual impairments are pervasive in their effect on the individual’s entire life: social, occupational, recreational, and familial life. Blindness, of all chronic illnesses and disabilities, is the second leading cause of inability to work, with visual impairments being historically correlated with underemployment, unemployment, and poverty [23]. Recent studies have also suggested that sensory impairments, including visual impairment increase the risk for mortality, especially among the elderly. Vision loss can affect one’s quality of life (QOL), independence, and mobility and has been linked to falls, injury, and worsening of mental health, cognition, social function, employment, and educational attainment. The economic impact of vision loss is also substantial. Individuals with VI experience more symptoms of depression than those without. The implications of childhood blindness and VI may be more significant because of greater life expectancies [10].

Rehabilitation:

It has been reported that proper management of individuals with VI can provide the same quality of life as that of normally sighted individuals [24]. Therefore, rehabilitation should be made accessible to every visually impaired person. A visually impaired person needs following types of rehabilitation:

Medical Rehabilitation:

This includes early identification of the visually impaired people and timely management which can be either medical or surgical management. Medical rehabilitation not only includes correction of refractive error, but prevention of any predisposing factors like early cataract surgery, timely management of retinal and optic nerve disease to stop progression and preserve the residual useful vision, vitamin A supplements among children. Low Vision Aids form an important part of medical rehabilitation of visually impaired people so that they can benefit from their residual useful vision. They are of two types, optical & non-optical.
1. Optical type: Spectacle magnifiers, Handheld and stand magnifiers, Microscopic lenses, Telescopic lenses, Projection devices etc.
2. Non-optical type: Large print books, Type writers, Typo scopes, Special illumination devices, Talking books etc.

Educational Rehabilitation:

Educational rehabilitation includes education avenues provided to the visually impaired in the residential blind schools with the facility of Braille system of education. Louis Braille’s invention of Braille alphabet system in 1832 provided a tremendous impetus to the education of visually impaired children throughout the world. After gaining primary education from these schools, these children are placed in regular schools in the general education system. This system of education that is, first Braille from special blind school and then learning from general schools in the presence of regular teachers as well as a resource teacher is known as integrated system of education. It aims at normalizing the life and education of visually impaired children in the least restrictive environment along with sighted children in general schools.

Vocational Rehabilitation:

Vocational rehabilitation aims at helping the visually impaired earn their livelihood and live as useful citizens. They are taught simple occupations like candle making, chalk making, book binding, chair canning etc. Rehabilitation intervention can affect coping patterns over time and that direction and magnitude of such an effect may depend on the type of rehabilitation received.

Psychosocial Rehabilitation:

It includes mobility training, training for basic life skills and social support. Mobility training can be provided with cane or guide person or devices. Visually impaired needs to have a good and efficient training in the use of his remaining senses so that he acquires some amount of independence in his mobility. Basic survival skills should be taught. The social support extended by family and community is very important.

Conclusion

The burden of visual impairment is prevalent in every country, be it developing or developed. Visual impairments do have profound consequences for the individual, however effective rehabilitation services can restore independence and therefore ameliorate these consequences and restore the individual’s quality of life. Therefore, proper counseling, timely referrals and appropriate low vision aids, trainings and rehabilitations are very important aspects of eye care and patient management.

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Friday, 2 November 2018

Presentatıon of a Temporal Artery Case with One Eye (TOOAJ)- Lupine Publishers






Temporal arteritis or giant cell arteritis(GCA), is a frequently seen systemic inflammatory vasculitis, affecting elderly people.Early treatment is very important to reduce the risk of future vision loss. In this report, we presented arteritic anterior ischemic optic neuropathy (AAION) in a late-diagnosed temporal arteritis. Interestingly, despite late diagnosis prompt improvement was seen and total blindness, the most worrisome complication of temporal arteritis, was prevented with urgent treatment. In this case report, we presented urgent treatment of the patient with AAION who is blind in one eye due to complicated cataract surgery. We reported the importance of prompt treatment and approach to patients who has already diagnosed with temporal arteritis.


Tuesday, 30 October 2018

Guide Lines for Wet AMD Treatment (TOOAJ)- Lupine Publishers



To give practical guide lines for the management of neovascular AMD.Macular laser photocoagulation [Macular Photocoagulation Study (MPS) can result in preventing severe loss of vision in about 50 percent of treated patients with extra/ juxta foveal CNV, with about 50 percent of patients developing recurrent choroidal neovascular membrane (CNVM).Photodynamic therapy (PDT) with verteporfin acts via activating a photosensitizing dye within the pathologic vessels by infrared laser leading to occlusion of choroidal new vessels with minimal damage to the retina. PDT can prevent 3-line vision loss in about 49 to 77 percent of treated patients but seldom improves vision .With the establishment of VEGF as the main cause for the development and progression of neovascularization, novel agents to block them and thereby preventing further progression was sought for. With the advent of anti-VEGF agents, the treatment for neovascular AMD has completely changed, with dramatic outcomes.

Wednesday, 10 October 2018

Open Access Automation in Vision Testing: Glaucoma Detection Software (TOOAJ)- Lupine Publishers



Vision testing is the phenomenon of detecting the vision problems which are generally undertaken to improve prognosis and disabilities. Apart from visual acuity measurement and refractive error problems, other eye related retinal disorders include diabetic retinopathy, age related muscular degeneration and glaucoma. Retinal imaging plays an important role in the detection of these disorders. Early detection of these disorders can prevent the permanent vision loss in patients. The aim of this research work is to implement a software algorithmic program in the field of ophthalmology for the detection of glaucoma. In the present work, Glaucoma detection is done by cup to disc ratio measurement to locate the damaged optic nerve head. DRIVE database is used to acquire retinal images. Further codes are implemented using MATLAB software to get the results. This software system can be utilized everywhere, especially in school health programs in Himachal Pradesh in urban as well as rural areas where it is difficult to carry high maintenance ophthalmic machines.


Thursday, 4 October 2018

Comparison of Invasive & Non-Invasive Tear Break up Time Measurement Techniques in Contact Lens Users (TOOAJ)-Lupine Publishers



To compare invasive and non-invasive techniques for measuring tear break-up time (TBUT) in contact lens users.Comparison of invasive and non-invasive TBUT was done on a sample of 30 contact lens users (60eyes) ages limit from 15 to 30 years of females at Department of Ophthalmology, Madinah Teaching Hospital (MTH) Faisalabad by applying non probability convenient sampling technique. This descriptive cross sectional study was completed in duration of 6 months from October 2018 to March; 2018. An appropriate informed consent was taken from each participant under study. Video keratograph and Bausch and Lomb keratometer were used to measure non-invasive tear break up time. Flourescein tear break up time was performed by Slit Lamp using flourscein strip. Averages of three readings were recorded of each technique to ensure accuracy. Data was analyzed by One-way ANOVA test in SPSS software version 20. There is insignificant difference between invasive and non-invasive TBUT technique at level of 5% confidence interval.There is no significant difference between values of invasive and non invasive tear break up time. Each of three techniques can be applied for measuring tear film stability.


Thursday, 27 September 2018

Pachychoroid Neovasculopathy Within The Spectrum of Pachychoroid Disease (TOOAJ)-Lupine Publishers




Pachychoroid neovasculopathy is a relatively new retinal disease, characterized by the presence of Type 1 choroidal neovascularization associated with signs of increased choroidal thickening and hyperpermeability. The latter features are distinctive of pachychoroid spectrum disease, which also includes pachychoroid pigment epitheliopathy, central serous chorioretinopathy and polypoidal choroidal vasculopathy. These pathologies share common features, such as choroidal vascular disfunction, abnormalities of the retinal pigment epithelium without showing typical characteristics of age related macular degeneration and, occasionally, choroidal new vessels. Many recent works have tried to analyze the main aspects of pachychoroid neovasculopathy with the aim to better understand the natural course and the proper management of the disease. Multimodal imaging modality, with the recent advent of the optical coherence tomography angiography, plays a fundamental role to help the physicians to distinguish choroidal neovascularization in pachychoroid disease from neovascular age related macular degeneration. In this review, we summarize the latest updates in the pathogenesis, clinical features, and advances in imaging multimodalities in order to delineate a clearer description of the pachychoroid neovasculopathy. Finally, we propose recommendation guidelines for the diagnosis and management of this relatively new clinical entity. Nevertheless, larger studies and clinical trials are needed to achieve standardized diagnostic criteria and treatment modalities.



Monday, 24 September 2018

Sequential Endogenous Endophthalmitis (TOOAJ)-Lupine Publishers




This report describes an unusual case of culture-proven bilateral endogenous endophthalmitis secondary to an underlying psoas abscess in a 54 year old male. The patient first was found to have endophthalmitis in the left eye, and, in spite of being on the appropriate intravenous antibiotics, he subsequently developed endophthalmitis in the right eye two days later With timely treatment and close communication with the primary team, the patient recovered with a successful visual outcome.


Thursday, 20 September 2018

Drug Targets and its Delivery in Glaucoma -Current Trend and Future Prospects (TOOAJ)-Lupine Publishers



Topical route of drug delivery always remained a route of choice for delivering all glaucoma medications rather than systemic route. Upon topical instillation drug reaches interior tissues of eye mainly through corneal route and route and therefore epithelial and stromal layer of the cornea act as barrier to transcorneal permeability of both hydrophilic and lipophilic drugs respectively. TTanscellular and Para cellular pathways are the two major corneal transportation routes for the topically applied drugs. Lipophillic drugs cross the cornea through transcellular pathway while the hydrophilic drugs cross through para cellular pathway. For treatment of glaucoma effective drugs are present mainly beta blockers, cholinergic agonists, carbonic anhydrase inhibitors, adrenergic agonists and prostaglandin derivatives but lack effective delivery system to improve patient care and clinical outcomes. Currently available drugs for ocular conditions need to be administered two or more i.e. multiple times a day, as well the poor patient adherence makes the treatment less clinically effective. Studies suggest that <1% of topically administered drug reaches aqueous humor. Up to 80% of systemic absorption of drug occurs followed by topical administration of eye drop causing systemic side effects.


Tuesday, 18 September 2018

Ophthalmology and Ionizing Radiation (TOOAJ)-Lupine Publishers



Due to the sensitive nature and low radiation tolerance of eye and its contents radiation to eye is sparingly and selectively used. Delivering ionizing radiation to eye associated with complications, however the intraocular tumors are highly radiosensitive and radiation can be delivered both by external beam therapy and brachytheray. Due to recent advances in radiotherapy now particle beam therapy is preferred for best vision sparing therapy due its selective nature. External and brachytherapy can radiation used with intent of radiacal, adjuvant and palliative intent to most common intraocular tumors like retinoblastoma, choroidal melanoma and metastatic tumors. Brachytherapy rarely is used only in selective centers with high technical expertise due high professional exposure to ionizing radiation. Radiation plaques are used in brachytherapy and these are the preloaded sources kept near the tumors either temporarily or permanently. Brachytherapy most commonly used for choroid melanomas. Brachytherapy plaques come in different sizes and shapes or can be customized according to the needs. Brachytherapy basically delivers high radiation to tumor and less radiation to surrounding normal tissues.


Friday, 10 August 2018

Trends in Ophthalmology: Open Access Journal (TOOAJ) - Lupine Publishers

Trends in Ophthalmology Open Access Journal (TOOAJ) is a peer-reviewed, international journal of Lupine group that publishes research articles, review articles, and clinical studies related to the sense of sight. This Journal includes new diagnostic and treatment methods, surgical techniques, instrument updates and the latest drug findings. This journal focuses on different aspects of eye surgery such as post lasik conditions and care, surgically induced astigmatism, cataract surgery, corneal transplant success rate, clear corneal incision, post-operative corneal melt, malyugin ring cataract surgery. It also provides major reviews and also publishes manuscripts covering regional issues in a global context.

http://www.lupinepublishers.com/tooaj/