Antioxidant Properties and Antibacterial Activities of Leptadenia hastata Leaves Extracts on Staphylococcus aureus by Isaac John Umaru in DDIPIJ in Lupine Publishers
Leptadenia hastata extracts were evaluated for antibacterial activity and antioxidant properties. The leaf of the plant was
extracted with n-hexane, dichloromethane, ethyl acetate, chloroform and methanol to give respective extracts. The Antibacterial
activity against Staphylococcus aureus, was determined by disc diffusion method. Antioxidant activity was assayed by the DPPH
radical scavenging activity mechanism. The results showed that of n-hexane, ethyl acetate, dichloromethane, chloroform and
methanol extracts of Leptadenia hastata, methanol extract and chloroform extracts displayed more activity with 1.10 ± 0.10ab
and 0.97 ± 0.06ab than others at 25-1000ppm/desk of the extracts tested. The most antioxidant activities against DPPH were
displayed by the hexane and methanol extracts of Leptadenia hastata
leaf, exhibiting IC50 (63.44μg/mL) and IC50 (46.80μg/mL)
respectively, followed by chloroform, dichloromethane and lastly ethyl
acetate crude extract. The present results showed potential
of the medicinal plant used by traditional herbal medical practitioners
as natural anti-microbial, antioxidant and potentially antiinflammatory
agents. The results confirm that Leptadenia hastata leaves extracts can be used as a source of drugs to fight infections
caused by susceptible bacteria.
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