Journal of Chemical Sciences-Lupine Publishers

Biological Studies, Synthesis, Structural, Spectral Characterization and Co-Ordinate Mn (II), Fe (II), Zn (II) (II) Complexes Containing 2-Hydroxy-1- Naphthaldehydeand n,n’-Dimethyl-1,3-Propanediamine in Kadhiravan S in An archive of organic and inorganic chemical sciences in Lupine Publishers

A new Manganese (II), Iron (II), Zinc (II), complex, has been and characterized by elemental analysis, UV-Vis, FT-IR and Binding of this Mn (II), Fe (II), Zn (II) complex with calf thymus DNA was investigated by UV-Visible absorption, fluorescence spectroscopy techniques. The intrinsic binding constants Kb of complex with CT-DNA, BSA obtained from UV-Vis absorption studies were 1.75X1 05,1.98X105and2.38X105M-1.

Metal chelates are capable to tolerate their antitumor effects by binding to DNA. DNA binding alters the replication of DNA by inhibiting the growth of the tumor cells, which is the basis of designing new and more effective antitumor drugs. Among the DNA binding modes, intercalation is the most significant one because it always leads to cellular degradation [1]. Intercalation is the insertion of small molecules between stacked base pairs of the double helix structure of DNA. It leads to subsequent disruption of base stacking in the double helix by creating interference in hydrogen bonding or vander Waals interactions and results in the destabilization of double helix conformation of DNA. Thus, the consequence of intercalation include inhibition of transcription, prevention of DNA synthesis, structural changes of DNA, disturbances in cellular processes and finally cell death. More consideration has been paid on DNA intercalation, since the other DNA binding need more investigation for structure-function relationship. The groove binders along with intercalations can also be used for the treatment of bacterial, fungal infections and cancer.

https://lupinepublishers.com/chemistry-journal/fulltext/biological-studies-synthesis-structural-spectral-characterization-and-co-ordinate-mn-ii-fe-ii-zn-ii-ii-complexes-containing-2-hydroxy-1-naphthaldehydeand.ID.000140.php

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Lupine Publishers-Gynecology Journals

Correlation between Ultrasound Findings of EctopicPregnancy And Operative Findings in Sudanese Women by Hassan A Elkheir in IGWHC in Lupine Publishers.

Implantation of pregnancy outside the normal endometrial cavity called an ectopic pregnancy, which accounts for about 10% of all pregnancy-related deaths, despite improved diagnostic methods leading to earlier detection and effective treatment [1]. Also, it increases the chances of secondary infertility as well as incidence of the subsequent ectopic pregnancy [2]. The percentages of the women with ectopic pregnancy go to an emergency department with first trimester bleeding, pain, or both about (6 to 16%) [3]. Which is strongly associated with an increased incidence of pelvic inflammatory disease [4]. Symptoms may present in both ruptured and enraptured cases [5]. Ectopic pregnancy should be suspected in any woman of reproductive age with these symptoms, especially those who have risk factors for an extrauterine pregnancy [6]. The diagnosis is usually made clinically, based upon results of the imaging studies (ultrasound) and laboratory tests (hCG). The diagnosis can also be made by observation of the ectopic gestation at surgery or histopathological examination [7]. Transvaginal ultrasound (TVUS) is the principle approach used for sonographic evaluation of pregnancy of unknown location. TVUS allows for earlier and more reliable detection of an intrauterine or ectopic pregnancy (abdominal pregnancies are an exception) and for more reliable detection of a fetal heartbeat compared with transabdominal ultrasound (TAUS) [7]. A pseudosac can be seen in up to 20 percent of women with an ectopic pregnancy [8]. An extraovarian adnexal mass, seen in 89 to 100 percent of women with ectopic pregnancy, is the most common.com finding in tubal pregnancy.

This is a descriptive, prospective hospital-based study .It was conducted in Omdurman Maternity Hospital and Omdurman New Hospital. Sudan, during the period from August 2014 to Jan 2015 all women diagnosed clinically and by ultrasound with ectopic pregnancy attended study area were included in the study. Time-frame sample size was be taken in a period of six months from August 2014 to Jan 2015. Variables assessed were: sociodemographic data, previous ectopic pregnancy, contraceptive usage, tubal pathology and surgery, PID, clinical presentation, ultrasound findings and intra-operative findings. Intra-operative findings were correlated with clinical presentation, examination, and ultrasound findings. Sensitivity and specificity was calculated. The data was collected by direct interview using predesigned questionnaire. Abdominal ultrasound, and/or vaginal ultrasound were done to all the patients according to clinical presentation. Ultrasound was done by senior obstetrician and radiologist. The data was analyzed by computer program; statistical package for social science (SPPS), results presented in tables and graphs. The test of significance was be calculated by P value (0.05: 95% confidence). Written consent was obtained from SMSB provided to the hospital administration. Women consent was obtained verbally. Privacy of data collected was considered.

https://lupinepublishers.com/gynecology-women-health-journal/fulltext/correlation-between-ultrasound-findings-of-ectopic-pregnancy-and-operative-findings-in-sudanese-women.ID.000103.php 

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Forces Acting on A Bearing of an Electric Motor for The Railway Carriage Rounding A Curve (ARME)-Lupine Publishers

 

Forces Acting on A Bearing of an Electric Motor for The Railway Carriage Rounding A Curve by Ryspek Usubamatov in ARME in Lupine Publishers

Recent  investigations  in  gyroscope  effects  have  demonstrated  that  their  origin  has  more  complex  nature  that  represented  in  known publications. On a gyroscope are acting simultaneously and interdependently eight inertial torques around two axes. These torques are generated by the centrifugal, common inertial and Coriolis forces as well as the change in the angular momentum of  the masses of the spinning rotor. The action of these forces manifests the inertial resistance and precession torques on any rotating objects.  New  mathematical  models  for  the  inertial  torques  acting  on  the  spinning  rotor  demonstrate  fundamentally  different  approaches for solving of gyroscope problems in engineering. This is the very important result because the stubborn tendency in engineering  is  expressed  by  the  increasing  of  a  velocity  of  rotating  objects.  The  numerous  designs  of  the  movable  machines  and  mechanisms contain spinning components like turbines, rotors, discs and others lead to the proportional increase of the magnitudes of inertial forces that are forming their processes of work. This work considers the inertial torques acting on the on a rotor of an electric railway carriage rounding a curve, which expresses the gyroscopic effects.

https://lupinepublishers.com/robotics-mechanical-engineering-journal/fulltext/forces-acting-on-a-bearing-of-an-electric-motor-for-the-railway-carriage-rounding-a-curve.ID.000104.php



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Lupine Publishers-Journal of Diabetes and Obesity

Nocuous Skin Manifestations of Spironolactone:Drug Induced Leukocytoclastic Vasculitis by
Awad Magbri in ADO in Lupine Publishers.

83 year-old Caucasian female with past medical history of hypertension, chronic kidney disease stage3-4 secondary to hypertensive nephrosclerosis with minimal proteinuria, hypokalemia, and Sjugrene syndrome without extra-glandular involvement. The patient was admitted to hospital because of urinary tract infection and edema of the lower extremities. She was treated with antibiotics, and diuretics for the edema. Her blood pressure was not optimum at this visit and spironolactone 25mg was added to her medication to control her BP, hypokalemia, and proteinuria. She was on amlodipine, frusemide, clonidine, Irbesartan, and potassium supplement. The treating nephrologist decided to try spironolactone for better control of high BP and hypokalemia and phased out the potassium supplementation. At this encounter her micro-albumin-creatinine ratio was 379.3mg/ gr, (normal value <29.9mg/gr creatinine). Physical examination was otherwise normal except bilateral leg edema, and high blood pressure (149/65mmHg). Her estimated glomerular filtration rate (EGFR) was 28ml/min).

She returned to the nephrology clinic after 2 weeks for bilateral lower extremities itch, burning and painful rash involving the buttocks, upper thighs and shins bilaterally as shown in the (Figures 1 & 2). The rash was palpable, purpuric nodules symmetrically distributed over the lower extremities. She was sending for dermatological opinion and skin biopsy of the rash. The biopsy was consistent with leukocytoclastic vasculitis. On further questioning the patient, she recalled that she had had a similar rash long time ago when she was placed on “aldactone” and the doctor had to stop the medication because of the rash, subsequently, the rash went away. This triggered discontinuation of the spironolactone and she was treated with prednisone and topical steroids by the dermatologist. The current rash faded away in 3-4 weeks; however, she was still on 5mg of prednisone when she was last seen in the clinic.Spironolactone is potassium sparing mineral ocorticoid receptor antagonist (MRA) which acts on the distal tubules and collecting ducts of the kidneys and antagonizing the effect of aldosterone, thereby causing inhibition of sodium and chloride re absorption, and potassium secretion in the distal tubules. The bioavailability of spironolactone is 73%, and it is >90% protein-bound. The drug is extensively metabolized in the liver and excreted by renal (47- 57%), bile and eventually fecal route (35-41%). The elimination half-life of the drug ranges from 1.4 to 15- hours depending on the type of metabolites. It is indicated for heart failure with reduced ejection fraction, hypertension especially when associated with hyperaldosteronism, hypokalemia, precocious puberty, hirsutism and female virilization syndrome. The American geriatric association (AGS) recommends that the drug should be avoided in patients >65 years old when creatinine clearance <30ml/minute due to increased potassium levels associated with the medication [1]. Spironolactone has also been used for liver cirrhosis with as cites and diabetic nephropathy with proteinuria. It can be added to patients with metabolic alkalosis with hypokalemia due to diuretic use.To know more click on below link.

https://lupinepublishers.com/diabetes-obesity-journal/fulltext/nocuous-skin-manifestations-of-spironolactone-drug-induced-leukocytoclastic-vasculitis.ID.000103.php

 

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How does the open access publishing of journals like Lupine Publisher's impact the world of research?

Open Access means that electronic scholarly research journals which are freely available on the Web to all users, with no license restrictions needed. In Open Access Journals Publishers researcher can maximize the impact of their work as the potential readership is far greater than that for publications where the full text is restricted to subscribers only. Open access publications also go through the same peer review process as non-open access publications. Open access does not interfere with a decision to accomplishment results commercially. The ethics propulsive the Open Access Policy that the outputs from publicly funded research should be publicly available to researchers and to potential users in education, business, institute and public sectors, and to the general public. It has become widely accepted in the scientific community that Open access promotes knowledge and enables innovation. Some researchers are still not fully aware of the benefits of Open access Journals publishers, or are doubtful about any direct positive impact. In recent study a citation advantage shows that for open access journals are affected that way If only 49% of the articles will Open access, they have an average citation count of 9.04, while non-open access articles have a lower citation count, at only 5.76. While it can increase the level of citations, open access journals is not the only factor that shapes citations to published work. The reputation of the journal depend upon only the promotion by the publisher, and the field of research can have an important impact on the citation level. The positive impact of Open Access Journals Publishers on citations and visibility is only the growing body of work. Increasingly, scholarly journals is becoming more widely accessible in multiple ways. Some journals are fully accessible to the public at no charge. Others are accessible in large part or for most issues. Still others are accessible to most of their expected audience under wide license agreements. If the journal is accessible by its expected audience, then the components of journal quality, such as the profile of its editorial board, its ability to attract excellent articles and so on, will continue to be paramount, whoever pays for its production.

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Journal of veterinary science - Lupine Publishers

New Tool Explains Live Mycobacteria Found in Retail Milk by Berwyn Clarke in CDVS in Lupine Publishers

Most consumers of dairy products accept that pasteurization provides a guarantee that products are safe to eat and drink. However, research [1] using a new highly sensitive technology has revealed that live mycobacteria can exist in retail milk even after pasteurization and explains how this may happen. Live Mycobacterium avium subspecies paratuberculosis (MAP) - which causes Johne’s disease in cattle and has been implicated in Crohn’s disease in humans - was found in just over 10% of shop-bought pasteurized milk samples that were tested in the UK. The prevalence of MAP is higher than previous studies have shown due to the high sensitivity of the new phage-based technology that was used to conduct the milk testing. In the study of 386 samples of retail-purchased milk, Actiphage was able to detect live mycobacteria at levels as low as 1-2 cells per 50ml in comparison to other tests that cannot detect cell-counts lower than 100 cells. There is a growing body of research that implicates MAP in the development of Crohn’s disease [2], with MAP found in the bowel tissue of a proportion of patients with the condition. Although no causal relationship between MAP and Crohn’s has been directly established the dairy industry recognizes that limiting human exposure to MAP would be sensible on a precautionary principle [3]. Furthermore, there are clinical trials underway with anti-mycobacterial drugs that are directly assessing the benefit in Crohn’s disease. Some retailers are already removing dairy farmers from their milk pool if they are not engaged with Johne’s control plans. 

The Actiphage assay, developed by PBD Biotech, uses a virus (phage) that finds, infects and replicates in viable mycobacteria cells. Within hours the virus breaks open the mycobacteria cells, releasing DNA determining whether live organisms were present in the sample. Previous quality control procedures to monitor the levels of MAP in pasteurized milk have been difficult as these mycobacteria are extremely slow growing. Culturing these bacteria takes up to 18 weeks to determine if any MAP cells have survived a food safety or control process and the sensitivity of the procedure is low. The new phage-based detection method, which was used within the research published in the Elsevier journal of Food Microbiology (September 2018) [1], allowed experiments to be performed quickly (6-8 hours); providing the insight dairy producers and processors need to further improve control measures. The test’s underlying biotechnology was originally used for the detection of human TB-under the FastPlaque brand - but was only suitable for use on sputum. Now the highly specific phage-based diagnostic has been optimized, so it can detect the presence of mycobacteria in blood or milk in just six hours. Contrary to previous hypotheses, this research also suggests that MAP does not enter the milk solely due to faecal contamination, but via somatic cells within the udder. This intracellular location and the fact that these cells appear to clump may help explain how the mycobacteria are protected against heat inactivation during pasteurization and could lead to new processing methods to ensure the mycobacteria are inactivated. Earlier published work in 2016 [4] using the same technology also demonstrated the presence of live MAP in infant formula milk further increasing the value of this technology as a screening tool.

https://lupinepublishers.com/dairy-veterinary-science-journal/fulltext/new-tool-explains-live-mycobacteria-found-in-retail-milk.ID.000141.php

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International Journal of Architecture- Lupine Publishers

Dynamic Analysis of a Real Footbridge Structure in a Najaf City by Saad Al Wazni in Trends in Civil Engineering and its Architecture in Lupine Publishers

The presented study consists of a dynamic analysis of a real pedestrian bridge structure of about 35m span over the highway connect Kufa and centre city of Najaf (Iraq). The main objective of this analysis were to assess whether the dynamic properties of footbridge structure meets the main safety requirements with the appropriate verification criteria. The extracted dynamic properties of the structural bridge model are natural frequency and mode shape. ANSYS software is used to perform the analysis by the way of APDL method. In this study, the first seven vibration modes of the bridge model are extracted. The dynamic characteristics extracted by modal analysis of the adopted bridge structural model exhibited the uncomfortable of vibration modes compared with European standards.

https://lupinepublishers.com/civil-engineering-journal/fulltext/dynamic-analysis-of-a-real-footbridge-structure-in-a-najaf-city.ID.000133.php

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Processing and Analysis of Large-Scale Seismic Signal in Hadoop Platform (ARME) - Lupine Publishers

Processing and Analysis of Large-Scale Seismic Signal in Hadoop Platform by Shahrukh Javed in ARME in Lupinepublishers

Seismic data are the data extracted from the digital readings of seismic  waves.  Seismic  waves  are  similar  to  the  recorded  echoes  what  we  make  on  the  top  of  rigged  cliff.  The  only  difference  is  that  these  seismic  waves  propagate  downwards.  In  our  modern  society, information increases in high speed and a large amount of data  resides  on  cloud  platform.  Over  1/3rd   of  total  digital  data  are  produced yearly which needs to be processed and analyzed. Huge-live  digital  data  like  seismic  data,  where  even  a  small  amount  of  information  impacts  greatly  to  human  life  has  to  be  analyzed  and  processed  to  obtain  more  valuable  information  [1].  Thus,  Hadoop 
ecological  system  comes  into  picture,  which  is  easy  to  develop  &  process applications of mass data, has high fault tolerance nature, being developed on java platform and an open source, and ensures deployment of system [2]. 

https://lupinepublishers.com/robotics-mechanical-engineering-journal/fulltext/processing-and-analysis-of-large-scale-seismic-signal-in-hadoop-platform.ID.000103.php


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How to Become a Manufacturing Cell Fully-Automated Without Robots: Case-Study in the Automotive Components Industry

How to Become a Manufacturing Cell Fully-Automated Without Robots: Case-Study in the Automotive Components Industry by F J G Silva in ARME in Lupinepublishers

Productivity  is  a  key  factor  for  companies  manufacturing  parts  and  sets  to  the  automotive  industry.  Automation  plays  an  important  role  in  this  matter,  allowing  development  of  entire  manufacturing  cells  without  the  direct  need  of  workers.  Even  in  countries where the labour cost is relatively low, it becomes necessary to improve the level of automation applied to manufacture
cells  and  reduce  the  dependence  of  the  human  labour  unpredictability,  also  increasing  the  quality  and  reducing  the  costs.  This  case  study  was  developed  based  on  an  industrial  request  in  order  to  improve  a  semi-automatic  cell  devoted  to  seat  suspension  mat manufacturing. The original cell allows several automatic operations but it needs two workers for two specific operations not considered  in  the  initial  design.  Thus,  new  concepts  of  wire  feeding  and  manipulation  were  developed  in  order  to  allow  a  better  material flow throughout the cell. The new cell was designed and built with success, allowing obtain a fully-automated system, which leads to a better productivity and reliability of the manufacturing process.

https://lupinepublishers.com/robotics-mechanical-engineering-journal/fulltext/how-to-become-a-manufacturing-cell-fully-automated-without-robots-case-study.ID.000102.php


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Lupine Publishers-Journal of Reproductive Medicine

Prevalence of Postpartum Depression and AssociatedFactors among Postnatal Women Attending At HiwotFana Specialized University Hospital, Harar, East Ethiopia,2015/2016 by Sisay Shewasinad in OAJRSD in Lupine Publishers.

Postpartum depression also known as postnatal depression is a non psychotic depressive disorder of variable severity and it can begin as early as two weeks after delivery and can persist indefinitely if untreated. Most of the time, it occurs within the first three month after delivery. The illness can cause distress and impair a mother’s ability to carry out her normal tasks, care for herself and care of her baby. It is a clinical depression with symptoms that can include a feeling of fatigue, social withdrawal, sadness, changes in sleeping and eating patterns, and guilt (including related to ability to care for the infant), crying, loneliness and low self esteem lasting longer than two weeks or beginning two weeks or more after delivery [1,2]. The term “Post¬partum Depression” encompasses several mood disorders that follow childbirth. Important developments in the study of PPD include its association with symptoms of anxiety and bipolar disorders in addition to those of depression [2].

Becoming a mother can be difficult this is due to a major psychological shift from viewing oneself as a woman who is pregnant to viewing oneself as a new mother. This major emotional shift may create problems. Following childbirth, seesawing emotions and heightened emotional responses may occur [3]. The biological mechanism of PPD is believed to coincide with that of major depressive disorder. Depression in general is a disease of neuronal circuit integrity, which has been shown in studies by a reduction in brain volume of individuals diagnosed with major depressive disorder. Interestingly, the amount of volume loss correlates directly with the number of years of ill¬ness. Stress and depression act to reduce numerous brain pro¬teins that promote neuronal growth and synapse formation, and antidepressant medications have been shown to increase these and other protective proteins, thereby reversing the mechanism of depression.

These underlying neurobiological changes result from developmental interactions between genetic susceptibility and environmental factors (i.e., the psychosocial stresses ac¬companying motherhood) rather than a simple “chemical im¬balance,” as previously believed. Specifically, the neurobiolog¬ical effects of rapid postpartum hormone withdrawal predispose women with established risk factors to PPD. An interesting distinction that makes PPD unique from other depressive disorders is that it is marked by a prominent anxi-ety component. This may be why so many cases of PPD are missed, as many clinicians use the Patient Health Question¬naire which covers depressed mood and dysphoria, but not anxiety-as their primary screening technique. The stress of caring for a newborn or even the circumstances surrounding labor and delivery may precipitate the first symp¬toms of PPD.

Multiple risk factors for postpartum depression have been suggested as no single cause has been identified. Personal vulnerability, personal traits and social factors such as unplanned pregnancy occupational instability, single parenthood and marital discord have been cited. The effects of postnatal depression on the mother, her marital relationship, and her children make it an important condition to diagnose, treat and prevent. The mother unable to provide care to her infant as manifested by decreased adherence to regular check up well baby visits and increased frequency health care provider’s visits due to infant problems. Lastly depressed mothers have lower rates of gratification and enjoyment in their mothering role compared with non-depressed mothers. The patterns of symptoms in women with postpartum depression are similar to those in women who have depression unrelated to childbirth apart from the fact that the content may focus on the delivery or baby. Evidence from epidemiological and clinical studies suggests that mood disturbances following childbirth are not significantly different from affective illnesses that occur in women at other times.

https://lupinepublishers.com/reproductive-medicine-journal/fulltext/prevalence-of-postpartum-depression-and-associated-factors-among-postnatal-women-attending-at-hiwot-fana-specialized-university.ID.000102.php

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Journal of veterinary science- Lupine Publishers

Persistent Organic Pollutants and Heavy Metals and the Importance of Fish as a Bio-Indicator of Environmental Pollution by Nikola Puvača in CDVS in Lupine Publishers

Nowadays water pollution is the burning issue all over the world. Aquatic ecosystems are frequently contaminated with different toxicants through anthropogenic activities, and some of them such as metals may be naturally present and essential in low concentration but toxic and harmful in higher concentrations. Having in mind that not all chemical forms of pollutants are equally bioavailable, and some pollutants can be accumulated in living organisms to a greater extent than others, there is a need to study the levels of pollutants in the organisms to be able to predict the environmental risk. Thus, chemical analyses of the tissues of aquatic organisms are used as a routine approach in studies of aquatic pollution, providing a temporal integration of the levels of pollutants with biological relevance at higher concentrations than those present in water or sediment, and facilitating their quantification [1]. Fish are among the group of aquatic organisms which represent the largest and most diverse group of vertebrates. A number of characteristics make them excellent experimental models for toxicological research, especially for the contaminants which are likely to exert their impact on aquatic systems [2]. Due to feeding and living in the aquatic environments fish are particularly vulnerable and heavily exposed to pollution because they cannot escape from the detrimental effects of pollutants. Fish, in comparison with invertebrates, are more sensitive to many toxicants and are a convenient test subject for indication of ecosystem health. Heavy metals are produced from a variety of natural and anthropogenic sources. In aquatic environments, heavy metal pollution results from direct atmospheric deposition, geologic weathering or through the discharge of agricultural, municipal, residential or industrial waste products. Heavy metals are able to disturb the integrity of the physiological and biochemical mechanisms in fish that are not only an important ecosystem component, but also used as a food source. Previous studies have shown that marine and farmed fish and shellfish are significant contributors to consumer intake of some contaminants due to their presence in the aquatic environment and their accumulation in the flesh of fish and shellfish. The objective of this article is to describe the effects of different persistent organic pollutants and heavy metals on the fish used as bioindicator of environmental pollution. Fish have been found to be good indicators of water contamination in aquatic systems because they occupy different trophic levels; they are of different sizes and ages and in comparison with invertebrates, are also more sensitive to many toxicants [3]. Last but not least, fish are the final chain of aquatic food web and an important food source for human. Therefore, some toxicants in aquatic environments can be transferred through food chain into humans.

https://lupinepublishers.com/dairy-veterinary-science-journal/fulltext/persistent-organic-pollutants-and-heavy-metals-and-the-importance-of-fish-as-a-bio-indicator-of-environmental-pollution.ID.000131.php

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Introducing Deep Mind Learning Modeling (ARME) - Lupine Publishers

Introducing DeepMind Learning Modeling by Sadique Shaikh in ARME in Lupine Publishers

Since 2010 Google & Uber researchers and engineers are engaged in DeepMind project with registered company in UK and USA. DeepMind. Google used to “Deep reinforcement learning” to implement DeepMind technology. We can see the results of DeepMind learning with live examples of Google Assistance, Google Echo- Smart Speaker and Google home assistance, Google AI-God and AI Church, Amazon Alexa, Amazon echo, Apple Siri. Google is one the strong player in DeepMind learning technology but two major players also Amazon and Apple after Google. This technology brings next wave in future about to 2029 but also spoiling human ethics when AI became more then of human intelligence. This short communication discussed fundamental aspect related to DeepMind
designing and engineering with the help of model. 

https://lupinepublishers.com/robotics-mechanical-engineering-journal/fulltext/introducing-deepmind-learning-modeling.ID.000101.php


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