Computational Analysis of Pharmacogenomic based Compatibility of Micro RNA in Regulatory Network of Psoriasis: A Bioinformatics approach to initiate thediscovery of Systemic biomarkers to treat Psoriasis by Harishchander Anandaram in OAJBEB in Lupine Publishers.
In the era of post genomics, performing a computational analysis to
understand the pharmacogenomic based regulation of Psoriasis with
respect to the principles of data mining and constructing a regulatory
network with respect to the principles of systems biology and analyzing
the network with respect to the principles of test statistic remains a
challenging task to execute. The challenge was approached by identifying
the associated genes of Psoriasis from PharmGkb and it was followed by
identifying the associated regulators (MicroRNAs and Transcription
Factors) from PharmacomiR/ RegNetworks. Finally the Compatibility of
miRNA in regulatory networks was analyzed by the statistical measures of
miRmap.
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