Journal of Chemical Sciences-Lupine Publishers

Biological Studies, Synthesis, Structural, Spectral Characterization and Co-Ordinate Mn (II), Fe (II), Zn (II) (II) Complexes Containing 2-Hydroxy-1- Naphthaldehydeand n,n’-Dimethyl-1,3-Propanediamine in Kadhiravan S in An archive of organic and inorganic chemical sciences in Lupine Publishers

A new Manganese (II), Iron (II), Zinc (II), complex, has been and characterized by elemental analysis, UV-Vis, FT-IR and Binding of this Mn (II), Fe (II), Zn (II) complex with calf thymus DNA was investigated by UV-Visible absorption, fluorescence spectroscopy techniques. The intrinsic binding constants Kb of complex with CT-DNA, BSA obtained from UV-Vis absorption studies were 1.75X1 05,1.98X105and2.38X105M-1.

Metal chelates are capable to tolerate their antitumor effects by binding to DNA. DNA binding alters the replication of DNA by inhibiting the growth of the tumor cells, which is the basis of designing new and more effective antitumor drugs. Among the DNA binding modes, intercalation is the most significant one because it always leads to cellular degradation [1]. Intercalation is the insertion of small molecules between stacked base pairs of the double helix structure of DNA. It leads to subsequent disruption of base stacking in the double helix by creating interference in hydrogen bonding or vander Waals interactions and results in the destabilization of double helix conformation of DNA. Thus, the consequence of intercalation include inhibition of transcription, prevention of DNA synthesis, structural changes of DNA, disturbances in cellular processes and finally cell death. More consideration has been paid on DNA intercalation, since the other DNA binding need more investigation for structure-function relationship. The groove binders along with intercalations can also be used for the treatment of bacterial, fungal infections and cancer.

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