Preparation and Evaluation of Microparticulate Drug Delivery Systems of GliclazideEmploying Starch Acetate by KPR Chowdary in DDIPIJ in Lupine Publishers.
Recently much
emphasis is being laid on the development of micro particulate DDS in
preference to single unit systems because of their potential benefits
such as increased bioavailability, reduced risk of systemic toxicity,
reduced risk of local irritation and predictable gastric emptying. The
objective of the present study is to prepare and evaluate micro
particulate drug delivery systems of Gliclazide using starch acetate, a
new modified starch for oral controlled release. The starch acetate (DS
2.75) was freely soluble in chloroform and insoluble in several aqueous
fluids and organic solvents. Chloroform could be used as solvent for
starch acetate in the preparation of micro particles, microcapsules and
in film coating Spherical starch acetate- Gliclazide micro particles
could be prepared by the emulsification-solvent evaporation method. The
method is industrially feasible as it involves emulsification and
removal of the solvent, which can be controlled precisely. The
emulsification solvent evaporation method was reproducible with regard
to size and size distribution of the micro particles. About 65-70% of
micro particles in each batch were in the size range 35/50 mesh
(398.5μm) Encapsulation efficiency was in the range 96.0-99.3 % in the
preparation of micro particles. Gliclazide release from the starch acetate micro particles was slow
and spread over longer periods of time. The drug release depended on the
proportion of core: coat in the micro particles. A good linear
relationship (R2=0.826) between percent coat and release rate (ko) was observed.
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