Thursday 13 June 2019

Lupine Publishers-Drug Designing Journal

Recently much emphasis is being laid on the development of micro particulate DDS in preference to single unit systems because of their potential benefits such as increased bioavailability, reduced risk of systemic toxicity, reduced risk of local irritation and predictable gastric emptying. The objective of the present study is to prepare and evaluate micro particulate drug delivery systems of Gliclazide using starch acetate, a new modified starch for oral controlled release. The starch acetate (DS 2.75) was freely soluble in chloroform and insoluble in several aqueous fluids and organic solvents. Chloroform could be used as solvent for starch acetate in the preparation of micro particles, microcapsules and in film coating Spherical starch acetate- Gliclazide micro particles could be prepared by the emulsification-solvent evaporation method. The method is industrially feasible as it involves emulsification and removal of the solvent, which can be controlled precisely. The emulsification solvent evaporation method was reproducible with regard to size and size distribution of the micro particles. About 65-70% of micro particles in each batch were in the size range 35/50 mesh (398.5μm) Encapsulation efficiency was in the range 96.0-99.3 % in the preparation of micro particles. Gliclazide release from the starch acetate micro particles was slow and spread over longer periods of time. The drug release depended on the proportion of core: coat in the micro particles. A good linear relationship (R2=0.826) between percent coat and release rate (ko) was observed. 

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