Tuesday 28 August 2018

Anti Ulcer Activity of Leea Indica in Wistar Albino Rats: ANOAJ-Lupine Publishers

Objective: Leea indica is a well known plant with numerous pharmacological activities owing to the presence of the active constituents. Inspite of numerous therapeutic uses, efficacy of the plant in treating ulcers is not yet evaluated scientifically. Hence an attempt has been made to evaluate the Antiulcer activity of Leea indica.

Methods: The effect of Leea indica methanolic extract (LIME) on gastric ulcer in pylorus ligation-induced and aspirin induced models was studied by employing LIME at 200 mg/kg, 400 mg/kg. In both the models Ranitidine (40mg/kg) was employed as the standard. Depending on the model, parameters evaluated were total acidity, free acidity, volume and pH of gastric fluid, ulcer score and percent inhibition of ulcer index.

Results: Data were analyzed following graph pad instat version 3.0 followed by Dunnets multiple comparision test. LIME (400mg/ kg) significantly (P<0.01) reduced gastric ulcer index in pylorus ligation-induced and Aspirin induced ulcer models comparable to that of Standard drug. Histopathological studies confirmed that LIME (400mg/kg) possess anti ulcer activity in both models. The elicited activity might be owing to the existence of secondary metabolites such as flavonoids, tannins, and saponins.

Conclusion: Obtained results elucidate the Antiulcer activity of Leea indica methanolic extract. Further investigations on isolation of specific phyto chemicals and elucidating mechanisms of action are needed.

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