Nanoemulgel Innovative Approach for Topical Gel Based Formulation by
Bhupendra G Prajapati in Research and Reviews on Healthcare: Open Access Journal in Lupine Publishers
Bhupendra G Prajapati in Research and Reviews on Healthcare: Open Access Journal in Lupine Publishers
The lipophilic nature of majority of newly developed drugs has resulting
in poor bioavailability, and pharmacokinetic variations. The goal of
this evaluation is to evaluate and report the current potential and
future scope of nanoemulgel formulation for becoming an effective
delivery system for poorly water-soluble drugs. Nanoemulgel consist two
different systems in which drug containing nanoemulsionis incorporated
into a gel base. The fusion of these two systems makes this formulation
advantageous in several ways. Lipophilic drugs can be easily
incorporated and the skin permeability of the incorporated drugs can be
enhanced in several folds due to the finely distributed oil droplets in
gel phase. Simultaneously, it can be targeted more specifically to the
site of action and can avoid first pass metabolism and relieve the user
from gastric/systemic incompatibilities. The nanoemulgel drug delivery
system is a formulation related intervention to improve drug absorption
and therapeutic profile of lipophilic drugs. An increasing trend in
nanoemulgel use in recent years has been noticed because of the better
acceptability of the preparation to the patients due to their
non-greasy, convenience spreadability, and easy applicability and good
therapeutic and safety profile. Despite having few limitations,
nanoemulgel formulation can be considered as potential and promising
candidates for topical delivery of lipophilic drugs in the future.
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