Globally, mental health disorders are increasingly prevalent worldwide with depression particularly contributed to the largest percentage of global disability (7.5% of all years lived with disability in 2015). It is more common in females than males affecting 4 -7% of women in reproductive age group [1]. Women with mild depression are treated with cognitive based therapy and antidepressants are used depending on the severity of the symptoms [2]. Utilizing antidepressants preconception and during pregnancy was assessed in wide range of studies to evaluate the risk of associated congenital anomalies. Ornoy et al reviewed the association between tricyclic antidepressants (TCA) and congenital anomalies. Early studies showed slight increase in the associated risk however the following large studies showed no association [2].
http://www.lupinepublishers.com/ddipij/abstracts/DDIPIJ.MS.ID.000128.php
http://www.lupinepublishers.com/ddipij/fulltext/DDIPIJ.MS.ID.000128.php
http://www.lupinepublishers.com/ddipij/pdf/DDIPIJ.MS.ID.000128.pdf
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