Friday 5 October 2018

Genetic Polymorphisms at 17 Y-STR loci in Uzbek Population: (PRJFGS) - Lupinepublishers

Haplotypes and allele frequencies for the 17 Y-chromosomal short tandem repeat (Y-STR) loci, DYS456, DYS389I, DYS390, DYS389II, DYS458, DYS19, DYS385a/b, DYS393, DYS391, DYS439, DYS635, DYS392, Y GATA H4, DYS437, DYS438 and DYS448 were determined in a sample of 1000 unrelated Uzbekistan males living in the regions of Tashkent (100), Fergana (75), Andijan (85), Namangan (55), Sirdarya (55), Djizax (80),Samarqand (80), Kashqadarya (75), Surxandarya (50), Buxara (100), Navoiy (50), Xorezm (97) and from Republic Karakalpakistan (98) using the Y-filer PCR Amplification Kit (Thermo Fisher Scientific).This population was demonstrated 1000 haplotypes, of which 899 were unique. The gene diversity was 0.9988 (standard error:0.005).The haplotype diversity calculated from the 17 Y-STR loci was 0.9967 and the discrimination capacity was 0.8990. The DYS385 locus showed the highest gene diversity value (0.8936), while the DYS391 locus showed the lowest gene diversity value (0.4934).

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