Luteal Phase Support using Oral Dydrogesterone-a Prospective Treatment for Future Replacing Micronized Vaginal Progesterone by Kulvinder Kochar Kaur in Open Access Journal of Reproductive System and Sexual Disorders (OAJRSD) in Lupinepublishers
Although micronized vaginal
progesterone is the accepted norm for use in luteal phase support (LPS) in
controlled ovarian stimulation (COS) that is used for in vitro fertilization
(IVF) cycles, recently importance of oral Dydrogesterone has got the importance
in lieu of its oral availability, cheap, no cumbersome side effects and no
definitive newer fetal side effects. After the LOTUS 1 trial with a multicenter
double placebo, double dummy design it has proved an equal efficacy if not
superiority of oral D, over micronized vaginal progesterone and it seems D
might soon become the standard of care for LPS in conventional IVF cycles
besides its routine indication for recurrent abortions.
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