Aim: To evaluate and assess the value of measuring calponin 1 serum level in maternal circulation as a predictability tool for
preterm labor within 1 week in cases affected with threatened preterm delivery.
Methodology: cases clinically presenting at 24-34 gestational weeks with threatened preterm labor undergone sample
collection for measuring calponin 1 serum level simultaneously with cervical length assessment. With follow up performed in a
prospective manner till time of birth assessment and perinatal clinical outcomes of recruited subjects have been collected and
tabulated for analysis.
Results: One hundred forty-seven patients affected by
threatened preterm labor symptoms, between 24 and 33 + 6gestational
weeks have been enrolled in the research study. 71cases (48.3%)
delivered within 1 week from admission (group-A) and the
remaining 76 cases (51.7%) delivered after 1 week from admission
(group-B). Statistical correlations between the time interval
between admission and delivery and cervical length& calponin-1 at
admissions were significantly positive (0.387, p<0.001) &
significantly negative (-0.470, p<0.001) respectively while it was
between cervical length and calponin-1 at admissions significantly
negative (-0.413, p<0.001). Cervical length and calponin-1 at
admissions had moderate Diagnostic performance in predicting
delivery within 1 week from admission that not markedly increased if
having any of them or by combination in a regression equation.
Conclusion: measuring and evaluating calponin 1 level in
maternal serum could be a useful biological marker in short-range
time period for predictability of preterm delivery within patients
affected by threatened preterm delivery clinical presentation,
besides cervical length dimension measuring.
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