Reversal of Rocuronium-Induced Neuromuscular Block with Neostigmine in the Libyan Patients by Abdul M Gbaj in LOJPCR in Lupinepublishers
Background: Reversal of the enduring effect of rocuronium by neostigmine is a common procedure performed in the Libyan
hospitals. The reversal of the continuing effect of rocuronium by neostigmine was also evaluated.
Methods: eighty adult surgical patients were included in the study using neostigmine 2.5mg (0.05-0.07mg/kg) to reversal the
block induced by rocuronium 0.6 mg/kg. Anaesthesia was induced and maintained using i.v. propofol (2.5mg/kg) and fentanyl
(1.5µg/kg). Reversal neuromuscular function was monitored using clinical signs includes patient responsiveness, subjective
measurements of muscle strength (5 second head lift, hand grasp), eye opening, and tongue extrusion.
Results: Reversal of block was sustained in all patients from the enduring effect of rocuronium by neostigmine. Ninety-six
patients were had a similar time of recovery but eleventh were not. There were no serious adverse effects from neostigmine and no
significant changes in any measure of safety.
Conclusions: neostigmine is capable of reversing rocuronium-induced blockade in the Libyan patients by monitoring the
muscle strength, eye opening, and tongue extrusion.
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