Plant food contains numerous nutritional & anti-nutritional
compounds, which prevents various non-communicable diseases
such as cancer. This paper gives an overview of the cancer preventive
effect of brassica. In recent years, considerable attention has
been paid to cancer protective role of Brassica through major secondary
metabolites i.e. glucosinolates. Glucosinolates and their
breakdown products have been widely studied for their biological effect
on human and animal nutrition. These are responsible for
the secretion of detoxifying enzymes that remove carcinogens from the
organism. Furthermore, they activate proteins and II phase
detoxifying enzymes. They act as a major defence system to plants and
humans. However breakdown products of glucosinolates
e.g. isothiocyanate and indole regulates cancer cell development by
regulating target enzymes, which are involved in controlling
apoptosis and blocking of the cell cycle. The present paper reviews the
available literature on glucosinolates, their biosynthesis,
hydrolysis, their health promoting beneficial effects and possible role
in imparting defence against diseases especially cancer.
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