Improved Enantioselective Enzymatic Synthesis of (S) - Pregabalin: (AOICS) -Lupine Publishers

Improved Enantioselective Enzymatic Synthesis of (S) - Pregabalin by Madhuresh Sethi in Archive of organic and inorganic chemical sciences(AOICS) in Lupine Publishers

The manuscript aims to throw light on the route of synthesis of (3S)-3-(Amino methyl)-5-methylhexanoic acid: (PREGABALIN), which is a cost effective and efficient route. Pregabalin is a drug that is used in the treatment of epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder. This process of synthesis makes use of a liquid enzyme to avoid cost hike and improves the overall chiral purity of the final product accompanied with improved higher yields and purity. The investigational studies performed in this article will help improve the existing processes in certain aspects as discussed above.

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