Synthesis and Characterization of Novel Series of 1,2,4-Triazolo[3,4-b]-1,3,4-Thiadiazole Derivatives of Anilinoacetic Acids as Promising Antioxidant Agents by Balakrishna Kalluraya in Archive of organic and inorganic chemical sciences in Lupine Publishers
The preparation of a novel series of
6-arylaminomethyl-3-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles
(5) by the
cyclocondensation of 5-substituted-4-amino-3-mercapto-1,2,4-triazoles
(2) with appropriately substituted anilinoacetic acids (4)
employing phosphorous oxychloride is reported. The newly synthesized
compounds (5) were screened for their antioxidant activity
by DPPH radical scavenging assay and their structures were elucidated on
the basis of their 1H-NMR, IR, Mass spectral and elemental
analysis. Some of the tested compounds showed good DPPH radical
scavenger activities comparable to that of standard BHA.
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