Novel Techniques for Improving Anti-Cancer Efficacy via Synergistic Phototherapy by Jui Teng Lin, Kuo Ti Chen, and Hsia Wei Liu in Open Access Journal of Biomedical Engineering and Biosciences (OAJBEB) in Lupine Publishers
Factors influencing the cancer
therapy efficiency in both photothermal therapy (PTT) and photodynamic therapy
(PDT) using nanogold particles and photosensitizers, respectively, are
analyzed. In PTT, heat diffusion kinetics is used to calculate the temperature increase
resulted from the nanogold absorption of light energy, whereas photochemical
kinetics is used to find the efficacy of PDT, or the generation rate of
reactive oxygen species. Efficacy of cancer therapy may be enhanced by
combining PTT and PDT either activated by one light or two lights. For maximum
PTT/PDT synergistic efficacy, the concentration of photosensitizers and
nanogold required optimization, besides the wavelength of the light matching
the absorption peak of PS and nanogold, and the sequential order of PTT and PDT
process. External supply of either photosensitizers or oxygen concentration
will significantly improve the anti-cancer efficacy via type-II PDT.
Optimization is required for maximum synergic efficacy.
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